psychedelic medicine Archives - Evan MantriEvan Mantri

Category: psychedelic medicine Archives - Evan Mantri

April 19, 2013

Psilocybin MRIs and Dr. Carhart-Harris help elucidate the psychedelic state.

Very cool explanation of how the filter mechanism or ‘reducing-valve’ theory of consciousness and psychedelic states suggested by William James, Aldous Huxley and others was recently supported by brain MRIs of people experiencing psilocybin.

December 22, 2012


Amazing short film, loosely based on quotes from Terence Mckenna.

December 6, 2012

Rebekah Shaman Trailer

Teaser trailer for a documentary about a Western woman who trained with a Peruvian ayahuasca shaman.

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November 25, 2012

Eudea: A Technecovillage.

I’m introducing today, here at, Eudea; a wiki that aspires to help form an open source appropriate technology ecovillage: a technecovillage.

The vision is that of a testing ground for biomimetic and biomorphic design and fabrication, unified by pursuits of social and biological benefit, developing decentralization, automation and accessibility.

Essentially, it is a hackerspace on a village scale and an attempt to fuse the DIY/technological/maker movement with the arts, ecology and healing provinces of psychedelic culture:

Wiki-ville, maker-stead, hacker-habitat, tinker-town, and technologically-oriented ecovillage, Eudea will be a living laboratory for developing and prototyping affordable, accessible and replicable solutions to the challenges of food and energy production, economic and educational models, material scarcities, environmental accord, adapting to rapidly changing technologies and social landscapes, nurturing health and enhancing wellness.

So take a gander at the wiki, and feel free to register an account to add content or be included in a list of interested parties.

You can also keep up to date of any developments by liking our Facebook page or following us on Twitter.


November 25, 2012

Neuroplastic Mechanisms Elicited with Ketamine in Treatment-Resistant Depression

Ronald S. Duman, PhD and Professor of Psychiatry and professor of neurobiology and of pharmacology at Yale School of Medicine gives a presentation on the recent discoveries concerning the dramatic neuroplastic effects of ketamine, in which he states that this is “the most significant finding in the field of depression in over fifty years.”

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For more detailed look at psychedelic(and ketamine)-induced neuroplasticity and effects on depression, check out my paper;

The Doors of Reception: Functionally selective receptor mosaics and the plasticity-inducing psychedelics that bind them.

November 4, 2012

The Doors Of Reception; Psychedelics and Neuroplasticity

In the Spring of 2011 I wrote a research paper for my Molecular Neurobiology class at UC Berkeley, titled:

The Doors of Reception:
Functionally selective receptor mosaics
and the plasticity-inducing psychedelics that bind them.

I thought about seeking publication for it but never got around to it, so I figured I’d just share it here before more time kept passing.

It’s a somewhat technical review, so you’ll probably need some basic familiarity with cell biology and/or brain science to comprehend most of the jargon. If you are interested in psychedelic neuroscience, then I do, very much, encourage you to read it, because it reviews major and important advancements in the field of neuroscience (functional selectivity, receptor dimerizations & neuroplastic processes), how psychedelics tie them all together and the role they played in their discovery and elucidation, and touches upon the many implications these new paradigms have for medical and brain science in general, and psychedelic science in particular.

The content is about 18 pages long (double-spaced, 12 pt) and has 62 references.

If the report appears too technical or detailed for you, I also typed up a 3 page summary written in lay terms, although I do recommend the full report to get all the juicy psychedelic bits.

If you would like to learn about psychedelic biochemical neuroplasticity but find the main report inaccessible, try reading the summary first then digging in to the full report.

The full report can be found here.

And the brief layman’s summary here.


Anyone may republish the report online in part or in full, just let me know if you do and don’t forget to link back.


The ABSTRACT is as follows:

The past decade has seen many exciting new developments in neurobiology. Three particularly paradigm-rattling revelations reviewed in this report include; first, the elucidations of ‘functional receptivity,’ which expand multi-fold the elegant complexity of receptor function by showing that, not one, but rather, myriad unique cascades of intracellular signals leading to discrete profiles of gene activation can result from multiple receptor conformations, as opposed to merely an active or inactive state. Second: epigenetic and state-dependent neuroplasticity which suggests monumental therapeutic potential and challenges the status quos of biological reductionism and pharmaceutical industry. And last: receptor heteromerization wherein metabotropic receptors belonging to separate families form complexes engaging in functional, allosteric co-modulation and neurotransmitter signal integration, humbling the current level of neurological comprehension while presenting the potential for vastly improved pharmacological interventions. The author makes use of psychedelics as a vector connecting these exciting areas noting how they have played, and will continue to play, an indispensable role in their exploration.

 Read full report.

September 27, 2012

Sting talks about his Ayahuasca Experience

Beautiful animations:

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July 24, 2012

“Dirty Pictures” – Sasha Shulgin documentary online.

Documentary about the life and work of Sasha Shulgin:

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