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April 19, 2013

Psilocybin MRIs and Dr. Carhart-Harris help elucidate the psychedelic state.


Very cool explanation of how the filter mechanism or ‘reducing-valve’ theory of consciousness and psychedelic states suggested by William James, Aldous Huxley and others was recently supported by brain MRIs of people experiencing psilocybin.

December 22, 2012

Hyperspace

Amazing short film, loosely based on quotes from Terence Mckenna.

November 19, 2012

The Mushroom Man

3 minute short film about Paul Stamets.

November 4, 2012

The Doors Of Reception; Psychedelics and Neuroplasticity

In the Spring of 2011 I wrote a research paper for my Molecular Neurobiology class at UC Berkeley, titled:

The Doors of Reception:
Functionally selective receptor mosaics
and the plasticity-inducing psychedelics that bind them.

I thought about seeking publication for it but never got around to it, so I figured I’d just share it here before more time kept passing.

It’s a somewhat technical review, so you’ll probably need some basic familiarity with cell biology and/or brain science to comprehend most of the jargon. If you are interested in psychedelic neuroscience, then I do, very much, encourage you to read it, because it reviews major and important advancements in the field of neuroscience (functional selectivity, receptor dimerizations & neuroplastic processes), how psychedelics tie them all together and the role they played in their discovery and elucidation, and touches upon the many implications these new paradigms have for medical and brain science in general, and psychedelic science in particular.

The content is about 18 pages long (double-spaced, 12 pt) and has 62 references.

If the report appears too technical or detailed for you, I also typed up a 3 page summary written in lay terms, although I do recommend the full report to get all the juicy psychedelic bits.

If you would like to learn about psychedelic biochemical neuroplasticity but find the main report inaccessible, try reading the summary first then digging in to the full report.

The full report can be found here.

And the brief layman’s summary here.

 

Anyone may republish the report online in part or in full, just let me know if you do and don’t forget to link back.

 

The ABSTRACT is as follows:

The past decade has seen many exciting new developments in neurobiology. Three particularly paradigm-rattling revelations reviewed in this report include; first, the elucidations of ‘functional receptivity,’ which expand multi-fold the elegant complexity of receptor function by showing that, not one, but rather, myriad unique cascades of intracellular signals leading to discrete profiles of gene activation can result from multiple receptor conformations, as opposed to merely an active or inactive state. Second: epigenetic and state-dependent neuroplasticity which suggests monumental therapeutic potential and challenges the status quos of biological reductionism and pharmaceutical industry. And last: receptor heteromerization wherein metabotropic receptors belonging to separate families form complexes engaging in functional, allosteric co-modulation and neurotransmitter signal integration, humbling the current level of neurological comprehension while presenting the potential for vastly improved pharmacological interventions. The author makes use of psychedelics as a vector connecting these exciting areas noting how they have played, and will continue to play, an indispensable role in their exploration.

 Read full report.

October 2, 2012

Psychedelics in The Netherlands

by Evan 057 — Categories: drug-laws / drug-politics, psilocybin4 Comments

Guest-post by Johan Kralingen.

The Netherlands has always been known as the place to go for psychonauts and pot smokers, but at the moment there are many rumors going around that Amsterdam is changing its politics on drugs and tourism. Since 2008 it is illegal to sell magic mushrooms in The Netherlands, but cannabis can still be purchased in a cannabis café (or “coffeeshop” as they call them) although cannabis has never been a completely legal substance in The Netherlands. Not completely legal means that it is more a policy of tolerance that the government has decided on in the 70’s and it means that every adult is allowed to buy up to 5 grams of cannabis for personal usage a day from one of the 600 shops the country hosts in the different cities.

But now the government wants to make a new law and ban tourists from visiting the coffeeshops. In the Southern part of the country the law has already gone in effect and the plan is to also start banning tourists from the shops in the rest of the country starting from the 1st of January 2013. This however might not happen as the government has just changed and they might decide otherwise because of all the problems with street dealers it has caused in the south of the country.

Magic mushrooms however are strictly illegal in The Netherlands since 2008. The decision to ban mushrooms has been taken after a few incidents with foreigners. This concerned 8 incidents that later where proved to have nothing to do with mushrooms. The people involved in these incidents had consumed various drugs and a lot of alcohol, but for the government this was of course a great opportunity to place magic mushrooms on the list of prohibited substances.

Many organizations in The Netherlands have protested against this decision as some of the mushrooms are even growing in nature in The Netherlands. Smartshop owners and mushroom lovers have gotten very upset with the ban on mushrooms and are even today still trying to fight it. However the law does not prohibit the sale of mushroom spores and in the different smartshops in Amsterdam or from a smartshop online you can still buy many different magic mushroom spores to grow your own mushrooms. Also ready-to-grow magic mushroom kits have become very popular and many of them are still being sent all over the globe every year with The Netherlands as one of the biggest producers and exporters.

Even thought magic mushrooms are banned, you can still find some pretty interesting psychedelic stuff in Amsterdam and other cities in The Netherlands. Magic truffles for instance are known to have similar effects to mushrooms, but because they grow under the ground, they are not counted as mushrooms according to the Dutch laws and are legal. Also Ayahuasca and cactuses like San Pedro or Peyote are still available in many places in The Netherlands, as well as Energizers (natural stimulants and herbal party pills), that are still very popular amongst tourists and being sold over the internet to many countries in the world.

 

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(Disclaimer: Teleomorph.com supports the general business of honest smartshops and ethnobotanical resources, as well as the specific medicine focused on herein (psilocybin). While any links to businesses on Teleomorph.com will always be vetted for authenticity, reputation and trust-worthiness, responsibility for any information or product claims rests solely with the author and advertisers, and not Teleomorph.com.]

July 23, 2012

Psilocybin & Neurogenesis

Immensely fascinating research on the effects of psilocybin, 2c-c-NBOMe and ketanserine on leaning, unlearning and hippocampal neurogenesis:
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June 25, 2012

A Comparative Review of the Neuro-Psychopharmacology of Hallucinogen-Induced Altered States of Consciousness: The Uniqueness of Some Hallucinogens

I find it timely that this article was published right along with David Presti’s recent blog post The Nobel Prize that wasn’t, regarding Sasha Shulgin.

A Comparative Review of the Neuro-Psychopharmacology of Hallucinogen-Induced Altered States of Consciousness: The Uniqueness of Some Hallucinogens

Umit Sayin

Abstract

Altered states of consciousness induced by hallucinogens (H-ASC) is still a vaguely understood phenomenon. Taken the diverse psychological effects they exert, the main mechanism of action of hallucinogens; LSD, ibogaine, THC, PCP, MDMA, methamphetamine, mescaline, psilocybin and DMT, of which psychological effects are discussed in the article, are not properly understood and explained by the modern methods of neuroscience due to the lack of vigorous research. The involvement of some receptors, such as, 5-HT2 (and probably other 5-HT receptors), glutamate and dopamine receptors, adrenergic and cannabinoid receptors, is one of the mechanisms, however it is not easy to explain such incongruent psychological effects by only receptor and neurotransmitter systems alone, since H-ASCs have, sometimes, their own unity and gestalt, unfolding the subconscious, in the “voyages” they induce, although the perception may, or may not, be distorted depending on the person, and “set and setting”. They induce visual, tactile and auditory hallucinations; synesthesia; perception of fractals, geometrical and kaleidoscopic images with vivid colors; perception of two dimensional pictures as three dimensional, animated and moving; distortions and alterations in the body perception; alterations in the perceptions of temporal-spatial continuum and time; changes in the perception of the ego and the self; feelings of unification with nature and universe, peak experiences –mimicking satori or nirvana-, ecstasy, rapture, extreme euphoria, excitement and happiness, oceanic bliss, self-fulfillment, referred as “good trip”, as well as, dysphoria, anxiety, mania, delirium, psychosis, acute schizophrenia, collapse of the self, known as “bad trip”; depending upon the mood, affection and psychology of the person, and “set and setting”. Mysticomimetic effects of H-ASCs, imitate the consciousness states of ancient mystics, probably, by means of activating prefrontal cortex, limbic system and the right temporal lobe. A hypothetical “holographic brain theory” may give some extra insights about the explanation of some of the effects of H-ASCs. It should be taken into account that H-ASCs, can be accepted as a good tool to investigate the nature of consciousness, brain and the human psyche, as well as some of the H-ASCs are good models of psychosis, too. More detailed scientific research should be performed to understand the basic and real mechanisms of H-ASCs, to comprehend and unravel the mystery of human mind and consciousness, since scientific medical research on hallucinogens has been legalized since 1992.

Full Text: PDF Open Access

NeuroQuantology | June 2012 | Volume 10 | Issue 2 | Page 316-340

June 17, 2012

Rick Doblin: Will Psychedelic Medicine Transform Culture?

Nicely encompassing and optimistic talk given by Rick Doblin, president of MAPS, at the 2011 Entheogenesis Australis conference, on the current state and future trajectories of psychedelic research and how psychedelics might be integrated back into society.

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