pharmaceuticals Archives - Evan MantriEvan Mantri

Category: pharmaceuticals Archives - Evan Mantri

November 25, 2012

Neuroplastic Mechanisms Elicited with Ketamine in Treatment-Resistant Depression

Ronald S. Duman, PhD and Professor of Psychiatry and professor of neurobiology and of pharmacology at Yale School of Medicine gives a presentation on the recent discoveries concerning the dramatic neuroplastic effects of ketamine, in which he states that this is “the most significant finding in the field of depression in over fifty years.”

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For more detailed look at psychedelic(and ketamine)-induced neuroplasticity and effects on depression, check out my paper;

The Doors of Reception: Functionally selective receptor mosaics and the plasticity-inducing psychedelics that bind them.

November 4, 2012

The Doors Of Reception; Psychedelics and Neuroplasticity

In the Spring of 2011 I wrote a research paper for my Molecular Neurobiology class at UC Berkeley, titled:

The Doors of Reception:
Functionally selective receptor mosaics
and the plasticity-inducing psychedelics that bind them.

I thought about seeking publication for it but never got around to it, so I figured I’d just share it here before more time kept passing.

It’s a somewhat technical review, so you’ll probably need some basic familiarity with cell biology and/or brain science to comprehend most of the jargon. If you are interested in psychedelic neuroscience, then I do, very much, encourage you to read it, because it reviews major and important advancements in the field of neuroscience (functional selectivity, receptor dimerizations & neuroplastic processes), how psychedelics tie them all together and the role they played in their discovery and elucidation, and touches upon the many implications these new paradigms have for medical and brain science in general, and psychedelic science in particular.

The content is about 18 pages long (double-spaced, 12 pt) and has 62 references.

If the report appears too technical or detailed for you, I also typed up a 3 page summary written in lay terms, although I do recommend the full report to get all the juicy psychedelic bits.

If you would like to learn about psychedelic biochemical neuroplasticity but find the main report inaccessible, try reading the summary first then digging in to the full report.

The full report can be found here.

And the brief layman’s summary here.


Anyone may republish the report online in part or in full, just let me know if you do and don’t forget to link back.


The ABSTRACT is as follows:

The past decade has seen many exciting new developments in neurobiology. Three particularly paradigm-rattling revelations reviewed in this report include; first, the elucidations of ‘functional receptivity,’ which expand multi-fold the elegant complexity of receptor function by showing that, not one, but rather, myriad unique cascades of intracellular signals leading to discrete profiles of gene activation can result from multiple receptor conformations, as opposed to merely an active or inactive state. Second: epigenetic and state-dependent neuroplasticity which suggests monumental therapeutic potential and challenges the status quos of biological reductionism and pharmaceutical industry. And last: receptor heteromerization wherein metabotropic receptors belonging to separate families form complexes engaging in functional, allosteric co-modulation and neurotransmitter signal integration, humbling the current level of neurological comprehension while presenting the potential for vastly improved pharmacological interventions. The author makes use of psychedelics as a vector connecting these exciting areas noting how they have played, and will continue to play, an indispensable role in their exploration.

 Read full report.

August 15, 2012

Scientists can now block heroin, morphine addiction


In a major breakthrough, an international team of scientists has proven that addiction to morphine and heroin can be blocked, while at the same time increasing pain relief.

The team from the University of Adelaide and University of Colorado has discovered the key mechanism in the body’s immune system that amplifies addiction to opioid drugs.

Laboratory studies have shown that the drug (+)-naloxone (pronounced: PLUS nal-OX-own - a mirror-image drug to the widely known naloxone, or (-)-naloxone) will selectively block the immune-addiction response.

The results – which could eventually lead to new co-formulated drugs that assist patients with severe pain, as well as helping heroin users to kick the habit – will be published tomorrow in the Journal of Neuroscience.

Read more:

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July 24, 2012

Gary Null presents: WAR ON HEALTH – The FDA’s Cult of Tyranny

Hard hitting, new documentary from respected health guru Gary Null, about the horrific corruption systemic to the FDA. The video below includes an impassioned 1/2 introduction by director Null at the NYC premier. I was especially gripped by the second half of the film which touches on more diverse subjects than the first half, especially the look inside the FDA and how well-intended people employed by the governmental/corporate organization are kept silent.
Must see for those with an interest in deep politics or the standing medical and food systems and why and how they must be changed.

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May 6, 2012

Drug Quickly Reverses Alzheimer’s Symptoms in Mice

by Evan Mantri — Categories: biology, brain, cognition, health, pharmaceuticals, scienceLeave a comment

A drug rapidly clears amyloid from mice brains, quickly reversing the pathological, cognitive and memory deficits caused by the onset of Alzheimer’s.


February 26, 2012

Paul Stamets at TEDMED 2011

Must-See Paul Stamets TEDMED talk about some truly awe-inspiring developments in medicinal and economic mycology:

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December 19, 2011

Memory In Mice Dramatically Enhanced Using Genetics/Drug Combo

by Evan Mantri — Categories: biology, brain, cognition, medicine, pharmaceuticals, science, singularity, technology — Tags: Leave a comment

I was cramming for finals and thinking about how nice it would be to have this exact kind of technology, just as stumbled on this article:

December 4, 2011

The Ayahuasca Project

Definitely watch and share this trailer for a gorgeous looking documentary about ayahuasca shamanism, science and it’s use in treating Westerners afflicted with addictions and severe emotional traumas, as pioneered by the work of two doctors; Dr. Jacques Mabit, who “runs a legendary detox centre deep in the Peruvian jungle”and Dr. Gabor Maté, a lionhearted addiction specialist valiantly trying to establish a similar program in Canada.  It is seeking completion funding on KickStarter so if you like the trailer please learn more by watching the Kickstarter video.

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