In the Spring of 2011 I wrote a research paper for my Molecular Neurobiology class at UC Berkeley, titled:
The Doors of Reception:
Functionally selective receptor mosaics
and the plasticity-inducing psychedelics that bind them.
I thought about seeking publication for it but never got around to it, so I figured I’d just share it here before more time kept passing.
It’s a somewhat technical review, so you’ll probably need some basic familiarity with cell biology and/or brain science to comprehend most of the jargon. If you are interested in psychedelic neuroscience, then I do, very much, encourage you to read it, because it reviews major and important advancements in the field of neuroscience (functional selectivity, receptor dimerizations & neuroplastic processes), how psychedelics tie them all together and the role they played in their discovery and elucidation, and touches upon the many implications these new paradigms have for medical and brain science in general, and psychedelic science in particular.
The content is about 18 pages long (double-spaced, 12 pt) and has 62 references.
If the report appears too technical or detailed for you, I also typed up a 3 page summary written in lay terms, although I do recommend the full report to get all the juicy psychedelic bits.
If you would like to learn about psychedelic biochemical neuroplasticity but find the main report inaccessible, try reading the summary first then digging in to the full report.
The full report can be found here.
And the brief layman’s summary here.
Anyone may republish the report online in part or in full, just let me know if you do and don’t forget to link back.
The ABSTRACT is as follows:
The past decade has seen many exciting new developments in neurobiology. Three particularly paradigm-rattling revelations reviewed in this report include; first, the elucidations of ‘functional receptivity,’ which expand multi-fold the elegant complexity of receptor function by showing that, not one, but rather, myriad unique cascades of intracellular signals leading to discrete profiles of gene activation can result from multiple receptor conformations, as opposed to merely an active or inactive state. Second: epigenetic and state-dependent neuroplasticity which suggests monumental therapeutic potential and challenges the status quos of biological reductionism and pharmaceutical industry. And last: receptor heteromerization wherein metabotropic receptors belonging to separate families form complexes engaging in functional, allosteric co-modulation and neurotransmitter signal integration, humbling the current level of neurological comprehension while presenting the potential for vastly improved pharmacological interventions. The author makes use of psychedelics as a vector connecting these exciting areas noting how they have played, and will continue to play, an indispensable role in their exploration.
Read full report.