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Category: mdma Archives - Evan Mantri

July 24, 2012

“Dirty Pictures” – Sasha Shulgin documentary online.

Documentary about the life and work of Sasha Shulgin:

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June 25, 2012

A Comparative Review of the Neuro-Psychopharmacology of Hallucinogen-Induced Altered States of Consciousness: The Uniqueness of Some Hallucinogens

I find it timely that this article was published right along with David Presti’s recent blog post The Nobel Prize that wasn’t, regarding Sasha Shulgin.

A Comparative Review of the Neuro-Psychopharmacology of Hallucinogen-Induced Altered States of Consciousness: The Uniqueness of Some Hallucinogens

Umit Sayin


Altered states of consciousness induced by hallucinogens (H-ASC) is still a vaguely understood phenomenon. Taken the diverse psychological effects they exert, the main mechanism of action of hallucinogens; LSD, ibogaine, THC, PCP, MDMA, methamphetamine, mescaline, psilocybin and DMT, of which psychological effects are discussed in the article, are not properly understood and explained by the modern methods of neuroscience due to the lack of vigorous research. The involvement of some receptors, such as, 5-HT2 (and probably other 5-HT receptors), glutamate and dopamine receptors, adrenergic and cannabinoid receptors, is one of the mechanisms, however it is not easy to explain such incongruent psychological effects by only receptor and neurotransmitter systems alone, since H-ASCs have, sometimes, their own unity and gestalt, unfolding the subconscious, in the “voyages” they induce, although the perception may, or may not, be distorted depending on the person, and “set and setting”. They induce visual, tactile and auditory hallucinations; synesthesia; perception of fractals, geometrical and kaleidoscopic images with vivid colors; perception of two dimensional pictures as three dimensional, animated and moving; distortions and alterations in the body perception; alterations in the perceptions of temporal-spatial continuum and time; changes in the perception of the ego and the self; feelings of unification with nature and universe, peak experiences –mimicking satori or nirvana-, ecstasy, rapture, extreme euphoria, excitement and happiness, oceanic bliss, self-fulfillment, referred as “good trip”, as well as, dysphoria, anxiety, mania, delirium, psychosis, acute schizophrenia, collapse of the self, known as “bad trip”; depending upon the mood, affection and psychology of the person, and “set and setting”. Mysticomimetic effects of H-ASCs, imitate the consciousness states of ancient mystics, probably, by means of activating prefrontal cortex, limbic system and the right temporal lobe. A hypothetical “holographic brain theory” may give some extra insights about the explanation of some of the effects of H-ASCs. It should be taken into account that H-ASCs, can be accepted as a good tool to investigate the nature of consciousness, brain and the human psyche, as well as some of the H-ASCs are good models of psychosis, too. More detailed scientific research should be performed to understand the basic and real mechanisms of H-ASCs, to comprehend and unravel the mystery of human mind and consciousness, since scientific medical research on hallucinogens has been legalized since 1992.

Full Text: PDF Open Access

NeuroQuantology | June 2012 | Volume 10 | Issue 2 | Page 316-340

June 17, 2012

Rick Doblin: Will Psychedelic Medicine Transform Culture?

Nicely encompassing and optimistic talk given by Rick Doblin, president of MAPS, at the 2011 Entheogenesis Australis conference, on the current state and future trajectories of psychedelic research and how psychedelics might be integrated back into society.

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October 13, 2011

Providing a Better Living Through Chemistry to a Generation.

An exquisite 8 minute documentary-style interview with Nick Sand, the chemical revolutionary who synthesized the renowned Orange Sunshine and was the first person to discover the effects of DMT could be experienced by smoking it.

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June 17, 2011

VIdeo: Sasha Shulgin, 1987. 'Varieties of psychedelic experience'

by Evan Mantri — Categories: brain, chemistry, cognition, entheogens, lecture, mdma, research chems, science, video — Tags: Leave a comment

Video of Sasha Shulgin giving a talk about psychedelics in 1987 recorded by Sound Photosynthesis.  1 hour talk and 1 hour of questions: the talk is fun, especially taking into account the year it was given, but questions were rather mediocre in my opinion.

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parts 2 – 7 can be found here.

April 24, 2011

MAPS founder Rick Doblin answers questions from the Reddit community

Discussion of MAPS’ mission, psychedelic psychoterhapy and the progress towards medical approval of MDMA and psychedelics.

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February 15, 2011

O on E (and Addiction says MDMA doesn't make you stupid)

by Evan Mantri — Categories: brain, health, mdma, psychedelic medicine, science — Tags: 1 Comment

Oprah’s O Magazine has published a lengthy article about MDMA and it’s therapuetic applications based on a year’s worth of the author’s research.

and this is coming out at the same time that the journal Addiction published a paper about a $1.8 million, 5-year, NIDA-funded study by John Halpern of the neurocognitive consequences of Ecstasy use that “Shows Ecstasy Not Associated with Cognitive Decline.

February 1, 2011

Anonymous Engravings on Ecstasy Pills

by Evan Mantri — Categories: art, mdmaLeave a comment

Conceptual art book of pressed pill ecstasy designs.

“Like a modern-times archaeologist, Geneva-based artist FREDERIC POST hunted, collected and copied logos of Ecstasy pills during five years. Only interested in the visual dimension of these objects, he compiles his collection of drawings in a book entitled “Anonymous Engravings on Ecstasy Pills”, conferring thus value to an underground iconography of over 500 signs.”

He’s also made ecstasy jewelry.


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