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Category: ibogaine Archives - Evan Mantri

June 25, 2012

A Comparative Review of the Neuro-Psychopharmacology of Hallucinogen-Induced Altered States of Consciousness: The Uniqueness of Some Hallucinogens

I find it timely that this article was published right along with David Presti’s recent blog post The Nobel Prize that wasn’t, regarding Sasha Shulgin.

A Comparative Review of the Neuro-Psychopharmacology of Hallucinogen-Induced Altered States of Consciousness: The Uniqueness of Some Hallucinogens

Umit Sayin


Altered states of consciousness induced by hallucinogens (H-ASC) is still a vaguely understood phenomenon. Taken the diverse psychological effects they exert, the main mechanism of action of hallucinogens; LSD, ibogaine, THC, PCP, MDMA, methamphetamine, mescaline, psilocybin and DMT, of which psychological effects are discussed in the article, are not properly understood and explained by the modern methods of neuroscience due to the lack of vigorous research. The involvement of some receptors, such as, 5-HT2 (and probably other 5-HT receptors), glutamate and dopamine receptors, adrenergic and cannabinoid receptors, is one of the mechanisms, however it is not easy to explain such incongruent psychological effects by only receptor and neurotransmitter systems alone, since H-ASCs have, sometimes, their own unity and gestalt, unfolding the subconscious, in the “voyages” they induce, although the perception may, or may not, be distorted depending on the person, and “set and setting”. They induce visual, tactile and auditory hallucinations; synesthesia; perception of fractals, geometrical and kaleidoscopic images with vivid colors; perception of two dimensional pictures as three dimensional, animated and moving; distortions and alterations in the body perception; alterations in the perceptions of temporal-spatial continuum and time; changes in the perception of the ego and the self; feelings of unification with nature and universe, peak experiences –mimicking satori or nirvana-, ecstasy, rapture, extreme euphoria, excitement and happiness, oceanic bliss, self-fulfillment, referred as “good trip”, as well as, dysphoria, anxiety, mania, delirium, psychosis, acute schizophrenia, collapse of the self, known as “bad trip”; depending upon the mood, affection and psychology of the person, and “set and setting”. Mysticomimetic effects of H-ASCs, imitate the consciousness states of ancient mystics, probably, by means of activating prefrontal cortex, limbic system and the right temporal lobe. A hypothetical “holographic brain theory” may give some extra insights about the explanation of some of the effects of H-ASCs. It should be taken into account that H-ASCs, can be accepted as a good tool to investigate the nature of consciousness, brain and the human psyche, as well as some of the H-ASCs are good models of psychosis, too. More detailed scientific research should be performed to understand the basic and real mechanisms of H-ASCs, to comprehend and unravel the mystery of human mind and consciousness, since scientific medical research on hallucinogens has been legalized since 1992.

Full Text: PDF Open Access

NeuroQuantology | June 2012 | Volume 10 | Issue 2 | Page 316-340

June 17, 2012

Rick Doblin: Will Psychedelic Medicine Transform Culture?

Nicely encompassing and optimistic talk given by Rick Doblin, president of MAPS, at the 2011 Entheogenesis Australis conference, on the current state and future trajectories of psychedelic research and how psychedelics might be integrated back into society.

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June 25, 2011

UN attempting to outlaw all sacred plants (Ayahuasca, Iboga, etc.). SIGN PETITION!!

Important message from Luis Eduardo;

Dear friends,

I urge you to sign this petition. Once more, this is an attack against the cultural and spiritual heritage of non-western people, a continuation of conquest and colonization of the word by people with a very limited worldview.
Best regards,

Luis Eduardo

The United Nations International Narcotics Control Board (INCB) has published on their website their annual report about the world situation on drugs in 2010. In this report, the INCB has included the preoccupying recommendation towards governments to outlaw  traditional plants such as Ayahuasca (a decoction made with botanicals like Banisteriopsis Caapi and Psychotria Viridis) andTabernanthe Iboga among others, neglecting their important role as traditional medicine, as a sacrament and as therapeutic tool. These are the primary uses of these plants found in societies all over the world.

The International Center for Ethnobotanical Education, Research & Service (ICEERS) is organizing a letter-writing campaign to counter this demonic injustice.  Please read more about this issue and add your signature here, and take a moment to browse the beautiful website of ICEERS.org.

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March 11, 2011

Clare S. Wilkins: Data & Observations from Four-Hundred Ibogaine Sessions

Clare S. Wilkins, an ibogaine therapist and researcher, gives a phenomenal presentation about the dynamics, causes and treatments of addiction, at the 2010 NYC conference, Horizons: Perspectives on Psychedelics.  A must-see for anyone interested in addiction or ibogaine.

“Four-Hundred Ibogaine Sessions: Data on Detoxification, Recidivism, and Quality of Life.”

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December 17, 2010

Online Videos from the 2010 Horizons Conference

Videos from the 2010 “Horizons: Perspectives on Psychedelics” conference are now online. The conference took place on Sept. 24-26 at Judson Memorial Church in New York City. The available videos are:

  • Jeffrey Guss, M.D., “The NYU Psilocybin Cancer Anxiety Research Project’s Psychedelic Psychotherapy Training”
  • Matthew W. Johnson, Ph.D., and Mary P. Cosimano, M.S.W., “Psilocybin in Smoking Cessation: A Pilot Study”
  • Neal M. Goldsmith, Ph.D., “Psychedelics, Psychotherapy, and Change”
  • Jill Harris, “Challenges in Changing the Legal Status of Entheogens”
  • JP Harpignies, “Psychedelics, Utopianism, and Psycho-Spiritual Inflation”
  • Erik Davis, “Psychedelics: Between Natural and Supernatural”
  • Rick Strassman, M.D., “Old Testament Prophecy – A Western Model of the Psychedelic Experience


December 2, 2010

Psychedelic Science Conference Videos Online

MAPS has just uploaded 85 of the presentations from the medical conference: Psychedelic Science In The 21st Century.

There should still be more to come too, but in this batch are many phenomenal talks.   Lots immensely fascinating scientific and medical topics as well as many videos on ayahuasca topics.

Some non-technical presentations I recommend are:

~Carolyn “Mountain Girl” Garcia – On The Bus
~Shulgin Tribute Banquet
~Robert Jesse – Closing Talk (on the betterment of well people)
~Andrew Weil M.D. – The Future of Psychedelic Research

…to name but a few for there are countless wonderful presentations to peruse: MAPS.org

July 31, 2010

Popular Science on Ibogaine

Brief yet informative article:

Animal tests, however, have shown the drug’s medicinal promise. “Rats addicted to morphine will quit for weeks after receiving ibogaine,”

Fighting Drugs With Drugs: An Obscure Hallucinogen Gains Legitimacy as a Solution for Addictions


April 24, 2010

Ibogaine Addiction Treatment

by Evan Mantri — Categories: health, ibogaine, psychedelic medicine4 Comments

Martin Polanco, MD, founded the Ibogaine Clinic in Mexico that was featured in the beautiful documentary, Ibogaine: Rite of Passage.  He moved up to the bay area for a few years to work on a start-up
venture and is now working with a new clinic:


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