brain Archives - Evan MantriEvan Mantri

Category: brain Archives - Evan Mantri

April 19, 2013

Psilocybin MRIs and Dr. Carhart-Harris help elucidate the psychedelic state.

Very cool explanation of how the filter mechanism or ‘reducing-valve’ theory of consciousness and psychedelic states suggested by William James, Aldous Huxley and others was recently supported by brain MRIs of people experiencing psilocybin.

December 7, 2012

The BirdBuggy

by Evan Mantri — Categories: biology, brain, cognition, fun/funny, nature, technology, videoLeave a comment


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November 25, 2012

Neuroplastic Mechanisms Elicited with Ketamine in Treatment-Resistant Depression

Ronald S. Duman, PhD and Professor of Psychiatry and professor of neurobiology and of pharmacology at Yale School of Medicine gives a presentation on the recent discoveries concerning the dramatic neuroplastic effects of ketamine, in which he states that this is “the most significant finding in the field of depression in over fifty years.”

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For more detailed look at psychedelic(and ketamine)-induced neuroplasticity and effects on depression, check out my paper;

The Doors of Reception: Functionally selective receptor mosaics and the plasticity-inducing psychedelics that bind them.

November 4, 2012

The Doors Of Reception; Psychedelics and Neuroplasticity

In the Spring of 2011 I wrote a research paper for my Molecular Neurobiology class at UC Berkeley, titled:

The Doors of Reception:
Functionally selective receptor mosaics
and the plasticity-inducing psychedelics that bind them.

I thought about seeking publication for it but never got around to it, so I figured I’d just share it here before more time kept passing.

It’s a somewhat technical review, so you’ll probably need some basic familiarity with cell biology and/or brain science to comprehend most of the jargon. If you are interested in psychedelic neuroscience, then I do, very much, encourage you to read it, because it reviews major and important advancements in the field of neuroscience (functional selectivity, receptor dimerizations & neuroplastic processes), how psychedelics tie them all together and the role they played in their discovery and elucidation, and touches upon the many implications these new paradigms have for medical and brain science in general, and psychedelic science in particular.

The content is about 18 pages long (double-spaced, 12 pt) and has 62 references.

If the report appears too technical or detailed for you, I also typed up a 3 page summary written in lay terms, although I do recommend the full report to get all the juicy psychedelic bits.

If you would like to learn about psychedelic biochemical neuroplasticity but find the main report inaccessible, try reading the summary first then digging in to the full report.

The full report can be found here.

And the brief layman’s summary here.


Anyone may republish the report online in part or in full, just let me know if you do and don’t forget to link back.


The ABSTRACT is as follows:

The past decade has seen many exciting new developments in neurobiology. Three particularly paradigm-rattling revelations reviewed in this report include; first, the elucidations of ‘functional receptivity,’ which expand multi-fold the elegant complexity of receptor function by showing that, not one, but rather, myriad unique cascades of intracellular signals leading to discrete profiles of gene activation can result from multiple receptor conformations, as opposed to merely an active or inactive state. Second: epigenetic and state-dependent neuroplasticity which suggests monumental therapeutic potential and challenges the status quos of biological reductionism and pharmaceutical industry. And last: receptor heteromerization wherein metabotropic receptors belonging to separate families form complexes engaging in functional, allosteric co-modulation and neurotransmitter signal integration, humbling the current level of neurological comprehension while presenting the potential for vastly improved pharmacological interventions. The author makes use of psychedelics as a vector connecting these exciting areas noting how they have played, and will continue to play, an indispensable role in their exploration.

 Read full report.

September 27, 2012

Sharing Hackerspaces with the Rest of the World

Mitch Altman & Bilal Ghalib give an excellent half-hour talk at the 2011 World Maker Faire NY about what hackerspaces are:

September 26, 2012

Biohacking Reality

Great summary article about biohacking and DIY-Neuro over at Fast Company:

Biohackers And DIY Cyborgs Clone Silicon Valley Innovation

A new breed of hobbyists, scientists, and entrepreneurs are working on echolocation implants, brain-controlled software programs, and even cybernetic rats. Their experiments will change the future of tech.


August 24, 2012

Insane in the Color-Changing Membrane

Using DIY neuro equipment from Backyard Brains, the fast color changing chromatohores of squid skin were neurologically synchronized with signals from Cyprus Hill’s ‘Insane in the Membrane’:

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August 23, 2012

What Is DMT?

Video with excellent descriptions of DMT from Joe Rogan:
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